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South America Cruises: Cape Horn, Brazil and the Amazon

How Cape Horn, Brazil, Amazon and Galapagos cruises compare, the best months to go, where ships sail from, and what to pack.

By Shandolyn, Cruise Advisor at The Cruise Company · Updated October 2026

South America cruises range from glacier-lined fjords at the bottom of the world to tropical beaches in Brazil and a voyage up the Amazon. Many are longer, one-way trips. They suit travelers with time to spare who want to see wildlife, wild scenery and big cities in a single trip.

When to go

The main season runs from November through March, during the southern summer. Most large ships move to other regions for the rest of the year.

WhenWhat to expectGood for
NovemberLate spring in Patagonia. Cooler, with long days and fewer people.Cape Horn, Buenos Aires and Chile
December to FebruarySummer and peak season. Mildest weather in Patagonia, though wind is common. Hot and humid in Brazil.Cape Horn, Falklands, Brazilian beaches
MarchLate summer. Weather starts to cool in the far south. Brazil’s Carnival often falls in February or March.Brazil, end-of-season Patagonia sailings
April to OctoberFew ocean cruises in the south. Galapagos small ships sail year-round.Galapagos, river and expedition trips

Itinerary types compared

Cape Horn and Patagonia

The classic route sails between Buenos Aires and Valparaíso or San Antonio, the ports for Santiago, Chile, in about two weeks. Typical stops include Montevideo, Puerto Madryn, the Falkland Islands, Ushuaia, Punta Arenas and Puerto Montt. Scenic cruising covers the Beagle Channel, the Strait of Magellan, the Chilean fjords and, weather permitting, Cape Horn itself. Seas can be rough, and some calls, especially the Falklands, depend on wind and swell. Some voyages continue to Antarctica.

Brazil and the east coast

These cruises focus on Rio de Janeiro, Salvador and beach towns such as Búzios and Ilhabela, often combined with Montevideo and Buenos Aires. Expect warm weather, lively cities and plenty of beach time.

The Amazon

Ocean ships can sail about a thousand miles up the Amazon to Manaus, with stops at river towns along the way. These voyages often begin or end in Florida and include Caribbean ports. Smaller river ships in Peru and Brazil offer a closer look at the rainforest.

Galapagos and the west coast

The Galapagos Islands are visited on small expedition ships under strict national park rules. West coast voyages call at Lima (Callao), a common starting point for trips to Machu Picchu.

Where cruises leave from

Most Cape Horn and Brazil cruises start or end in Buenos Aires, Rio de Janeiro or Valparaíso and San Antonio. Some longer voyages, including many Amazon cruises, sail from Fort Lauderdale or Miami. Galapagos trips usually begin with a flight from mainland Ecuador.

Which cruise line?

Packing and travel documents

A valid passport is required. Entry rules differ by country and change over time, so check current requirements for every country on your route with each country and with your advisor. For the Amazon, ask your doctor or a travel clinic about recommended vaccinations and health precautions well before you go. Our US passport page covers applying and renewing.

Advisor tip: Cape Horn cruises are one-way, so plan flights into one city and home from another. Add at least two nights before the cruise in Buenos Aires or Santiago. It gives you a buffer for long flights and time to see two of the region’s best cities.

Browse sailings on our South America cruises page, or request a quote and an advisor will help you choose a route.

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